Article
Obesity in Humans Is Characterized by Gut Inflammation as Shown by Pro-Inflammatory Intestinal Macrophage Accumulation.
Frontiers in immunology - 1 Jan 2021
Rohm Theresa V, Fuchs Regula, Müller Rahel L, Keller Lena, Baumann Zora, Bosch Angela J T, Schneider Romano, Labes Danny, Langer Igor, Pilz Julia B, Niess Jan H, Delko Tarik, Hruz Petr, Cavelti-Weder Claudia
Abstract excerpt
Chronic low-grade inflammation is a hallmark of obesity and associated with cardiovascular complications. However, it remains unclear where this inflammation starts. As the gut is constantly exposed to food, gut microbiota, and metabolites, we hypothesized that mucosal immunity triggers an innate inflammatory response in obesity. We characterized five distinct macrophage subpopulations (P1-P5) along the...
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