Article
Bimodal expression of potential drug target CLL-1 (CLEC12A) on CD34+ blasts of AML patients.
European journal of haematology - 1 Sept 2021
Ngai Lok Lam, Ma Connie Y, Maguire Orla, Do An D, Robert Alberto, Logan Aaron C, Griffiths Elizabeth A, Nemeth Michael J, Green Cherie, Pourmohamad Tony, van Kuijk Bo J, Snel Alexander N, Kwidama Zinia W, Venniker-Punt Bianca, Cooper James, Manz Markus G, Gjertsen Bjørn T, Smit Linda, Ossenkoppele Gert J, Janssen Jeroen J W M, Cloos Jacqueline, Sumiyoshi Teiko
Abstract excerpt
OBJECTIVES: This study aims to retrospectively assess C-lectin-like molecule 1 (CLL-1) bimodal expression on CD34+ blasts in acute myeloid leukemia (AML) patients (total N = 306) and explore potential CLL-1 bimodal associations with leukemia and patient-specific characteristics. METHODS: Flow cytometry assays were performed to assess the deeper immunophenotyping of CLL-1 bimodality. Cytogenetic analysis was...
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