Novel strain-level resolution of Crohn’s disease mucosa-associated microbiota via an ex vivo combination of microbe culture and metagenomic sequencing

Abstract excerpt

The mucosa-associated microbiota is widely recognized as a potential trigger for Crohn's disease pathophysiology but remains largely uncharacterised beyond its taxonomic composition. Unlike stool microbiota, the functional characterisation of these communities using current DNA/RNA sequencing approaches remains constrained by the relatively small microbial density on tissue, and the overwhelming amount of human...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gut microbiota and health
• Share to Inflammatory Bowel Disease
• Share to Mycobacterium research and diagnosis