Article
Genetics of symptom remission in outpatients with COVID-19.
Scientific reports - 25 May 2021
Dubé Marie-Pierre, Lemaçon Audrey, Barhdadi Amina, Lemieux Perreault Louis-Philippe, Oussaïd Essaïd, Asselin Géraldine, Provost Sylvie, Sun Maxine, Sandoval Johanna, Legault Marc-André, Mongrain Ian, Dubois Anick, Valois Diane, Dedelis Emma, Lousky Jennifer, Choi Julie, Goulet Elisabeth, Savard Christiane, Chicoine Lea-Mei, Cossette Mariève, Chabot-Blanchet Malorie, Guertin Marie-Claude, de Denus Simon, Bouabdallaoui Nadia, Marchand Richard, Bassevitch Zohar, Nozza Anna, Gaudet Daniel, L'Allier Philippe L, Hussin Julie, Boivin Guy, Busseuil David, Tardif Jean-Claude
Abstract excerpt
We conducted a genome-wide association study of time to remission of COVID-19 symptoms in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA clinical trial. We found a significant association at 5p13.3 (rs1173773; P = 4.94 × 10-8) near the natriuretic peptide receptor 3 gene (NPR3). By day 15 of the study, 44%, 54% and 59% of participants with 0, 1, or 2 copies of the effect...
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