Article
Tracing genetic signatures of bat-to-human coronaviruses and early transmission of North American SARS-CoV-2.
Transboundary and emerging diseases - 1 Jul 2022
Ou Xumin, Yang Zhishuang, Zhu Dekang, Mao Sai, Wang Mingshu, Jia Renyong, Chen Shun, Liu Mafeng, Yang Qiao, Wu Ying, Zhao Xinxin, Zhang Shaqiu, Huang Juan, Gao Qun, Liu Yunya, Zhang Ling, Peppelenbosch Maikel, Pan Qiuwei, Cheng Anchun
Abstract excerpt
Highly pathogenic coronaviruses, including SARS-CoV-2, SARS-CoV and MERS-CoV, are thought to be transmitted from bats to humans, but the viral genetic signatures that contribute to bat-to-human transmission remain largely obscure. In this study, we identified an identical ribosomal frameshift motif among the three bat-human pairs of viruses and strong purifying selection after jumping from bats to humans. This...
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