Article
Effect of CHRFAM7A Δ2bp gene variant on secondary inflammation after spinal cord injury.
PloS one - 1 Jan 2021
Lin Mingkuan, Huang Wan, Kabbani Nadine, Theiss Mark M, Hamilton John F, Ecklund James M, Conley Yvette P, Vodovotz Yoram, Brienza David, Wagner Amy K, Robbins Emily, Sowa Gwendolyn A, Lipsky Robert H
Abstract excerpt
The α7 neuronal nicotinic acetylcholine receptors (α7nAChRs) are essential for anti-inflammatory responses. The human-specific CHRFAM7A gene and its 2bp deletion polymorphism (Δ2bp variant) encodes a structurally-deficient α7nAChRs that may impact the anti-inflammatory function. We studied 45 spinal cord injury (SCI) patients for up to six weeks post SCI to investigate the role of the Δ2bp variant on multiple...
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