Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial.

doi:10.1111/epi.16899

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial.

Epilepsia - 1 Jun 2021

Blümcke Ingmar, Coras Roland, Busch Robyn M, Morita-Sherman Marcia, Lal Dennis, Prayson Richard, Cendes Fernando, Lopes-Cendes Iscia, Rogerio Fabio, Almeida Vanessa S, Rocha Cristiane S, Sim Nam Suk, Lee Jeong Ho, Kim Se Hoon, Baulac Stephanie, Baldassari Sara, Adle-Biassette Homa, Walsh Christopher A, Bizzotto Sara, Doan Ryan N, Morillo Katherine S, Aronica Eleonora, Mühlebner Angelika, Becker Albert, Cienfuegos Jesus, Garbelli Rita, Giannini Caterina, Honavar Mrinalini, Jacques Thomas S, Thom Maria, Mahadevan Anita, Miyata Hajime, Niehusmann Pitt, Sarnat Harvey B, Söylemezoglu Figen, Najm Imad

Abstract excerpt

OBJECTIVE: Focal cortical dysplasia (FCD) is a major cause of difficult-to-treat epilepsy in children and young adults, and the diagnosis is currently based on microscopic review of surgical brain tissue using the International League Against Epilepsy classification scheme of 2011. We developed an iterative histopathological agreement trial with genetic testing to identify areas of diagnostic challenges in this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibody Diversity

Share to Immunohistochemistry

Share to Magnetic Resonance Imaging

Share to Malformations of Cortical Development

Share to Neurosurgical Procedures

Share to Observer Variation

Share to Seizures

Source

Open in PubMed

Identifiers

PMID: 33949696
DOI: 10.1111/epi.16899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toward a better definition of focal cortical dysplasia: An iterative histopathological and genetic agreement trial.PMID 33949696Read ↗

Toward a refined genotype-phenotype classification scheme for the international consensus classification of Focal Cortical Dysplasia.Semantic proximity Read ↗

Focal cortical dysplasia: a practical guide for neurologists.Semantic proximity Read ↗

Updates from the International League Against Epilepsy Classification of Epilepsy (2017) and Focal Cortical Dysplasias (2022): Imaging Phenotype and Genetic Characterization.Semantic proximity Read ↗

Deep tissue sequencing improves genetic diagnostic yield in focal cortical dysplasiaSemantic proximity Read ↗

Deep histopathology genotype-phenotype analysis of focal cortical dysplasia type II differentiates between the GATOR1-altered autophagocytic subtype IIa and MTOR-altered migration deficient subtype IIb.Semantic proximity Read ↗

Dissecting the genetic basis of focal cortical dysplasia: a large cohort studySemantic proximity Read ↗

Genotype‐phenotype correlations in focal malformations of cortical development: a pathway to integrated pathological diagnosis in epilepsy surgerySemantic proximity Read ↗

[Advances of pathological research and classification in malformations of cortical development associated with refractory epilepsy].Semantic proximity Read ↗

Somatic Mosaicism Patterns Define Clinical-Surgical Subtypes of Focal Cortical Dysplasia Through Cell-Type-Specific ExpressionSemantic proximity Read ↗

Genomic and Epigenetic Advances in Focal Cortical Dysplasia Types I and II: A Scoping ReviewSemantic proximity Read ↗

Protein Biomarker in Focal Cortical Dysplasia: Molecular Clues to PathogenesisSemantic proximity Read ↗

Review: Challenges in the histopathological classification of ganglioglioma and DNT: microscopic agreement studies and a preliminary genotype‐phenotype analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.