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Article

The role of NOTCH3 variants in Alzheimer's disease and subcortical vascular dementia in the Chinese population.

CNS neuroscience & therapeutics - 1 Aug 2021

Guo Lina, Jiao Bin, Liao Xinxin, Xiao Xuewen, Zhang Weiwei, Yuan Zhenhua, Liu Xixi, Zhou Lu, Wang Xin, Zhu Yuan, Yang Qijie, Wang Junling, Tang Beisha, Shen Lu

Abstract excerpt

AIMS: NOTCH3 gene mutations predominantly cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, a common etiology of subcortical vascular dementia (SVaD). Besides, there may be a pathogenic link between NOTCH3 variants and Alzheimer's disease (AD). We aimed to study the role of NOTCH3 variants in AD and SVaD patients. METHODS: We recruited 763 patients with dementia...

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Identifiers

PMID: 33942994
DOI: 10.1111/cns.13647
PMCID: PMC8265940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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