Article
Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii.
Nature communications - 3 May 2021
Luo Tao, Xu Peng, Zhang Yangyi, Porter Jessica L, Ghanem Marwan, Liu Qingyun, Jiang Yuan, Li Jing, Miao Qing, Hu Bijie, Howden Benjamin P, Fyfe Janet A M, Globan Maria, He Wencong, He Ping, Wang Yiting, Liu Houming, Takiff Howard E, Zhao Yanlin, Chen Xinchun, Pan Qichao, Behr Marcel A, Stinear Timothy P, Gao Qian
Abstract excerpt
Mycobacterium kansasii can cause serious pulmonary disease. It belongs to a group of closely-related species of non-tuberculous mycobacteria known as the M. kansasii complex (MKC). Here, we report a population genomics analysis of 358 MKC isolates from worldwide water and clinical sources. We find that recombination, likely mediated by distributive conjugative transfer, has contributed to speciation and on-going...
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