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Different phenotypes and chondrogenic responses of human menstrual blood and bone marrow mesenchymal stem cells to activin A and TGF-β3.

Stem cell research & therapy - 29 Apr 2021

Uzieliene Ilona, Bagdonas Edvardas, Hoshi Kazuto, Sakamoto Tomoaki, Hikita Atsuhiko, Tachtamisevaite Zivile, Rakauskiene Greta, Kvederas Giedrius, Mobasheri Ali, Bernotiene Eiva

Abstract excerpt

BACKGROUND: Due to its low capacity for self-repair, articular cartilage is highly susceptible to damage and deterioration, which leads to the development of degenerative joint diseases such as osteoarthritis (OA). Menstrual blood-derived mesenchymal stem/stromal cells (MenSCs) are much less characterized, as compared to bone marrow mesenchymal stem/stromal cells (BMMSCs). However, MenSCs seem an attractive...

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Identifiers

PMID: 33926568
DOI: 10.1186/s13287-021-02286-w
PMCID: PMC8082646

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