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Modeling Sialidosis with Neural Precursor Cells Derived from Patient-Derived Induced Pluripotent Stem Cells.

International journal of molecular sciences - 22 Apr 2021

Seol Binna, Kim Young-Dae, Cho Yee Sook

Abstract excerpt

Sialidosis, caused by a genetic deficiency of the lysosomal sialidase gene (NEU1), is a systemic disease involving various tissues and organs, including the nervous system. Understanding the neurological dysfunction and pathology associated with sialidosis remains a challenge, partially due to the lack of a human model system. In this study, we have generated two types of induced pluripotent stem cells (iPSCs)...

Topics

Astrocytes
Autophagy
Cell Differentiation
Humans
Induced Pluripotent Stem Cells
Lysosomes
Mucolipidoses
Mutation
Neural Stem Cells
Neuraminidase
Oligodendroglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Teratoma

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Open in PubMed Open full text

Identifiers

PMID: 33922276
DOI: 10.3390/ijms22094386
PMCID: PMC8122832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Modeling Sialidosis with Neural Precursor Cells Derived from Patient-Derived Induced Pluripotent Stem Cells.PMID 33922276Read ↗

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