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Article

Modeling Sialidosis with Neural Precursor Cells Derived from Patient-Derived Induced Pluripotent Stem Cells.

International journal of molecular sciences - 22 Apr 2021

Seol Binna, Kim Young-Dae, Cho Yee Sook

Abstract excerpt

Sialidosis, caused by a genetic deficiency of the lysosomal sialidase gene (NEU1), is a systemic disease involving various tissues and organs, including the nervous system. Understanding the neurological dysfunction and pathology associated with sialidosis remains a challenge, partially due to the lack of a human model system. In this study, we have generated two types of induced pluripotent stem cells (iPSCs)...

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Identifiers

PMID: 33922276
DOI: 10.3390/ijms22094386
PMCID: PMC8122832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modeling Sialidosis with Neural Precursor Cells Derived from Patient-Derived Induced Pluripotent Stem Cells.PMID 33922276Read ↗

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Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.Semantic proximity Read ↗

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