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Article

Impaired Expression of Cytoplasmic Actins Leads to Chromosomal Instability of MDA-MB-231 Basal-Like Mammary Gland Cancer Cell Line.

Molecules (Basel, Switzerland) - 8 Apr 2021

Dugina Vera, Shagieva Galina, Novikova Mariya, Lavrushkina Svetlana, Sokova Olga, Kireev Igor, Kopnin Pavel

Abstract excerpt

We have shown previously that two cytoplasmic actin isoforms play different roles in neoplastic cell transformation. Namely, β-cytoplasmic actin acts as a tumor suppressor, whereas γ-cytoplasmic actin enhances malignant features of tumor cells. The distinct participation of each cytoplasmic actin in the cell cycle driving was also observed. The goal of this study was to describe the diverse roles of cytoplasmic...

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Identifiers

PMID: 33917969
DOI: 10.3390/molecules26082151
PMCID: PMC8068389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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