Article
Late recurrence of lung adenocarcinoma harboring EGFR exon 20 insertion (A763_Y764insFQEA) mutation successfully treated with osimertinib.
Cancer genetics - 1 Aug 2021
Kunimasa Kei, Nishino Kazumi, Kukita Yoji, Matsumoto Shingo, Kawachi Hayato, Kawamura Takahisa, Inoue Takako, Tamiya Motohiro, Honma Keiichiro, Sugimoto Naotoshi, Yamasaki Tomoyuki, Imamura Fumio, Goto Koichi, Kumagai Toru
Abstract excerpt
The EGFR-A763_Y764insFQEA is a unique mutation among EGFR exon 20 insertion mutations in that it is associated with sensitivity to conventional EGFR-tyrosine kinase inhibitors. This mutation, which was not initially covered by conventional reverse transcription polymerase chain reaction (RT-PCR) genotyping method, has only been detected in clinical practice when a next-generation sequencing (NGS)-based cancer...
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