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Molecular follow-up of first-line treatment by osimertinib in lung cancer: Importance of using appropriate tools for detecting EGFR resistance mutation C797S.

Cancer genetics - 1 Aug 2021

Fanjat Y, Barazzutti H, Di Mauro I, Tabary-Martin L, Duranton-Tanneur V, Gimet S, Bérard H, Pedeutour F

Abstract excerpt

The C797S mutation encoded by EGFR exon 20 is classically observed as a tertiary event in EGFR-mutant non-small-cell lung carcinoma (NSCLC) primarily treated by first generation tyrosine kinase inhibitors (TKI) and secondarily treated by third-generation TKI, such as osimertinib, if the EGFR-T790M resistance mutation is detected. Recently, significant prolonged progression free survival has been observed...

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PMID: 34157597
DOI: 10.1016/j.cancergen.2021.06.001

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