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Article

A unique mode of keratinocyte death requires intracellular acidification

23 Apr 2021

Abstract excerpt

Significance In specific tissues, cell death does not represent the end of cell function. The death of the uppermost stratum granulosum keratinocytes (SG1 cells) facilitates their conversion into stratum corneum (SC) corneocytes. Such cells are not removed by efferocytosis as would occur after apoptosis or necrosis; instead, nonviable cell bodies contribute to the protective barrier function of the SC. The...

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PMID: 33893234
DOI: 10.1073/pnas.2020722118

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