Patient-centred outcomes and effect of disease progression on health status in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation receiving maintenance olaparib or placebo (SOLO1): a randomised, phase 3 trial.

doi:10.1016/S1470-2045(21)00098-X

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Patient-centred outcomes and effect of disease progression on health status in patients with newly diagnosed advanced ovarian cancer and a BRCA mutation receiving maintenance olaparib or placebo (SOLO1): a randomised, phase 3 trial.

The Lancet. Oncology - 1 May 2021

Friedlander Michael, Moore Kathleen N, Colombo Nicoletta, Scambia Giovanni, Kim Byoung-Gie, Oaknin Ana, Lisyanskaya Alla, Sonke Gabe S, Gourley Charlie, Banerjee Susana, Oza Amit, González-Martín Antonio, Aghajanian Carol, Bradley William H, Liu Joyce, Mathews Cara, Selle Frédéric, Lortholary Alain, Lowe Elizabeth S, Hettle Robert, Flood Emuella, Parkhomenko Elena, DiSilvestro Paul

Abstract excerpt

BACKGROUND: In the phase 3 SOLO1 trial, maintenance olaparib provided a significant progression-free survival benefit versus placebo in patients with newly diagnosed, advanced ovarian cancer and a BRCA mutation in response after platinum-based chemotherapy. We analysed health-related quality of life (HRQOL) and patient-centred outcomes in SOLO1, and the effect of radiological disease progression on health status....

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PMID: 33862001
DOI: 10.1016/S1470-2045(21)00098-X

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