Article
Comprehensive exploration of tumor mutational burden and immune infiltration in diffuse glioma.
International immunopharmacology - 1 Jul 2021
Kang Kai, Xie Fucun, Wu Yijun, Wang Zhile, Wang Li, Long Junyu, Lian Xin, Zhang Fuquan
Abstract excerpt
BACKGROUND: Immune checkpoint inhibitors (ICIs) have been used as a novel treatment for diffuse gliomas, but the efficacy varies with patients, which may be associated with the tumor mutational burden (TMB) and immune infiltration. We aimed to explore the relationship between the two and their impacts on the prognosis. METHODS: The data of the training set were downloaded from The Cancer Genome Atlas (TCGA)....
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