Article
Description of optochin-resistant Streptococcus pneumoniae due to an uncommon mutation in the atpA gene and comparison with previously identified atpC mutants from Brazil.
Scientific reports - 12 Apr 2021
Souza Aline R V, de Pina Sandrine E C M, Costa Natália S, Neves Felipe P G, Merquior Vânia L C, Peralta José Mauro, Pinto Tatiana C A, Teixeira Lúcia M
Abstract excerpt
Optochin susceptibility testing is a major assay used for presumptive identification of Streptococcus pneumoniae. Still, atypical optochin-resistant (Optr) pneumococci have been reported and this phenotype has been attributed to nucleotide substitutions in the genes coding for the F0F1ATPase. While substitutions in the atpC gene (c-subunit of ATPase) are more common and better characterized, data on mutations in...
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