Article
Fabrication of Adipose-Derived Stem Cell-Based Self-Assembled Scaffold under Hypoxia and Mechanical Stimulation for Urethral Tissue Engineering.
International journal of molecular sciences - 25 Mar 2021
Rashidbenam Zahra, Jasman Mohd Hafidzul, Tan Guan Hee, Goh Eng Hong, Fam Xeng Inn, Ho Christopher Chee Kong, Zainuddin Zulkifli Md, Rajan Reynu, Rani Rizal Abdul, Nor Fatimah Mohd, Shuhaili Mohamad Aznan, Kosai Nik Ritza, Imran Farrah Hani, Ng Min Hwei
Abstract excerpt
Long urethral strictures are often treated with autologous genital skin and buccal mucosa grafts; however, risk of hair ingrowth and donor site morbidity, restrict their application. To overcome this, we introduced a tissue-engineered human urethra comprising adipose-derived stem cell (ASC)-based self-assembled scaffold, human urothelial cells (UCs) and smooth muscle cells (SMCs). ASCs were cultured with ascorbic...
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