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Article

Structural and Functional Characterization of the ABCC6 Transporter in Hepatic Cells: Role on PXE, Cancer Therapy and Drug Resistance.

International journal of molecular sciences - 11 Mar 2021

Bisaccia Faustino, Koshal Prashant, Abruzzese Vittorio, Castiglione Morelli Maria Antonietta, Ostuni Angela

Abstract excerpt

Pseudoxanthoma elasticum (PXE) is a complex autosomal recessive disease caused by mutations of ABCC6 transporter and characterized by ectopic mineralization of soft connective tissues. Compared to the other ABC transporters, very few studies are available to explain the structural components and working of a full ABCC6 transporter, which may provide some idea about its physiological role in humans. Some studies...

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Identifiers

PMID: 33799762
DOI: 10.3390/ijms22062858
PMCID: PMC8000515

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