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Article

Impact of HBV infection on the association between HOTAIR SNPs and the risk of hepatocellular carcinoma: A mediation and interaction analysis.

Neoplasma - 1 Mar 2021

Cheng Jinqun, Liu Guiyan, Zhang Junguo, Liu Qing, Lin Zhifeng, Tian Nana, Lin Xinqi, Liu Li, Yu Xinfa, Gao Yanhui

Abstract excerpt

Previous studies have demonstrated that single nucleotide polymorphisms (SNPs) rs12427129 and rs3816153 in HOX transcript antisense intergenic RNA (HOTAIR) might interact with hepatitis B virus (HBV) infection to increase the risk of hepatocellular carcinoma (HCC). However, it is unclear whether HBV infection is a potential mediator between HOTAIR rs12427129, rs3816153, and HCC. This study, including 1262 HCC...

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Share to Carcinoma, Hepatocellular
Share to Case-Control Studies
Share to Genetic Predisposition to Disease
Share to Hepatitis B, Chronic
Share to Hepatitis B virus
Share to Liver Neoplasms
Share to Polymorphism, Single Nucleotide
Share to RNA, Long Noncoding

Source

Identifiers

PMID: 33797934
DOI: 10.4149/neo_2020_200812N852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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