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Article

Erlotinib Activates Different Cell Death Pathways in EGFR-mutant Lung Cancer Cells Grown in 3D Versus 2D Culture Systems.

Anticancer research - 1 Mar 2021

Lee Hyun-Kyung, Noh Min Hye, Hong Seung-Woo, Kim Seung-Mi, Kim Sung Hyun, Kim Yeong Seok, Broaddus V Courtney, Hur Dae Young

Abstract excerpt

BACKGROUND/AIM: Non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutation have been shown to have a good response to erlotinib, a receptor tyrosine kinase inhibitor of EGFR. In this study, we found that the cell death pathways activated by erlotinib in 2D and 3D culture systems are different. MATERIALS AND METHODS: The cell death pathways induced by erlotinib were evaluated by flow...

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PMID: 33788717
DOI: 10.21873/anticanres.14883

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