Article
Feline Spongy Encephalopathy With a Mutation in the ASPA Gene.
Veterinary pathology - 1 Jul 2021
Takaichi Yuta, Chambers James K, Shiroma-Kohyama Moeko, Haritani Makoto, Une Yumi, Yamato Osamu, Nakayama Hiroyuki, Uchida Kazuyuki
Abstract excerpt
Canavan disease is an autosomal recessive leukodystrophy caused by mutations in the gene encoding aspartoacylase (ASPA), which hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. A similar feline neurodegenerative disease associated with a mutation in the ASPA gene is reported herein. Comprehensive clinical, genetic, and pathological analyses were performed on 4 affected cats. Gait disturbance and head...
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