Article
Abnormal upregulation of cardiovascular disease biomarker PLA2G7 induced by proinflammatory macrophages in COVID-19 patients.
Scientific reports - 24 Mar 2021
Li Yang, Jiang Yongzhong, Zhang Yi, Li Naizhe, Yin Qiangling, Liu Linlin, Lv Xin, Liu Yan, Li Aqian, Fang Bin, Li Jiajia, Ye Hengping, Yang Gang, Cui Xiaoxian, Liu Yang, Qu Yuanyuan, Li Chuan, Li Jiandong, Li Dexin, Gai Zhongtao, Wang Shiwen, Zhan Faxian, Liang Mifang
Abstract excerpt
High rate of cardiovascular disease (CVD) has been reported among patients with coronavirus disease 2019 (COVID-19). Importantly, CVD, as one of the comorbidities, could also increase the risks of the severity of COVID-19. Here we identified phospholipase A2 group VII (PLA2G7), a well-studied CVD biomarker, as a hub gene in COVID-19 though an integrated hypothesis-free genomic analysis on nasal swabs (n = 486)...
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