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A four-gene signature predicts survival and anti-CTLA4 immunotherapeutic responses based on immune classification of melanoma

22 Mar 2021

Abstract excerpt

Cutaneous melanoma is the most malignant skin cancer. Biomarkers for stratifying patients at initial diagnosis and informing clinical decisions are highly sought after. Here we classified melanoma patients into three immune subtypes by single-sample gene-set enrichment analysis. We further identified a four-gene tumor immune-relevant (TIR) signature that was significantly associated with the overall survival of...

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PMID: 33753855
DOI: 10.1038/s42003-021-01911-x

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