Article
Fat mass and obesity-associated (FTO) gene epigenetic modifications in gestational diabetes: new insights and possible pathophysiological connections.
Acta diabetologica - 1 Aug 2021
Franzago Marica, Fraticelli Federica, Marchioni Michele, Di Nicola Marta, Di Sebastiano Francesca, Liberati Marco, Stuppia Liborio, Vitacolonna Ester
Abstract excerpt
AIMS: Gestational diabetes mellitus (GDM) can lead to short- and long-term complications for the child. Epigenetic alterations could contribute to explaining the metabolic disturbances associated with foetal programming. Although the role of the FTO gene remains unclear, it affects metabolic phenotypes probably mediated by epigenetic mechanisms. The aim of this study was to assess whether placental DNA epigenetic...
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