Article
Cytokine gene polymorphisms are associated with response to blinatumomab in B-cell acute lymphoblastic leukemia.
European journal of haematology - 1 Jun 2021
Jeyakumar Nikeshan, Aldoss Ibrahim, Yang Dongyun, Mokhtari Sally, Gendzekhadze Ketevan, Khaled Samer, O'Donnell Margaret, Palmer Joycelynne, Song Joo Y, Marcucci Guido, Stein Anthony S, Forman Stephen J, Pullarkat Vinod A, Chen Wei, Wu Xiwei, Nakamura Ryotaro
Abstract excerpt
Blinatumomab is a bispecific T cell-engaging antibody approved for treatment of relapsed/refractory (r/r) ALL, with 40%-50% complete response (CR)/CR with incomplete count recovery (CRi). Cytokine release syndrome (CRS) as a major adverse effect after blinatumomab therapy. Here, we evaluated the possible association between single-nucleotide polymorphisms (SNPs) in cytokine genes, disease response, and CRS in r/r...
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