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Targeting netrin‐3 in small cell lung cancer and neuroblastoma

15 Mar 2021

Abstract excerpt

The navigation cue netrin-1 is well-documented for its key role in cancer development and represents a promising therapeutic target currently under clinical investigation. Phase 1 and 2 clinical trials are ongoing with NP137, a humanized monoclonal antibody against netrin-1. Interestingly, the epitope recognized by NP137 in netrin-1 shares 90% homology with its counterpart in netrin-3, the closest member to...

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PMID: 33719214
DOI: 10.15252/emmm.202012878

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