Article
A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes' interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19.
PLoS computational biology - 1 Mar 2021
Ding Jun, Hostallero David Earl, El Khili Mohamed Reda, Fonseca Gregory Joseph, Milette Simon, Noorah Nuzha, Guay-Belzile Myriam, Spicer Jonathan, Daneshtalab Noriko, Sirois Martin, Tremblay Karine, Emad Amin, Rousseau Simon
Abstract excerpt
Abnormal coagulation and an increased risk of thrombosis are features of severe COVID-19, with parallels proposed with hemophagocytic lymphohistiocytosis (HLH), a life-threating condition associated with hyperinflammation. The presence of HLH was described in severely ill patients during the H1N1 influenza epidemic, presenting with pulmonary vascular thrombosis. We tested the hypothesis that genes causing primary...
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