Article
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection.
Nature immunology - 1 May 2021
Zuo Jianmin, Dowell Alexander C, Pearce Hayden, Verma Kriti, Long Heather M, Begum Jusnara, Aiano Felicity, Amin-Chowdhury Zahin, Hoschler Katja, Brooks Tim, Taylor Stephen, Hewson Jacqueline, Hallis Bassam, Stapley Lorrain, Borrow Ray, Linley Ezra, Ahmad Shazaad, Parker Ben, Horsley Alex, Amirthalingam Gayatri, Brown Kevin, Ramsay Mary E, Ladhani Shamez, Moss Paul
Abstract excerpt
The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern that waning immunity may predispose to reinfection. We analyzed the magnitude and phenotype of the SARS-CoV-2-specific T cell response in 100 donors at 6 months following infection. T cell responses were present by ELISPOT and/or intracellular cytokine staining analysis in all donors and characterized by predominant CD4+ T...
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