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Article

Prevalence of germline pathogenic variants in 22 cancer susceptibility genes in Swedish pediatric cancer patients.

Scientific reports - 5 Mar 2021

von Stedingk Kristoffer, Stjernfelt Karl-Johan, Kvist Anders, Wahlström Cecilia, Kristoffersson Ulf, Stenmark-Askmalm Marie, Wiebe Thomas, Hjorth Lars, Koster Jan, Olsson Håkan, Øra Ingrid

Abstract excerpt

Up to 10% of pediatric cancer patients harbor pathogenic germline variants in one or more cancer susceptibility genes. A recent study from the US reported pathogenic variants in 22 out of 60 analyzed autosomal dominant cancer susceptibility genes, implicating 8.5% of pediatric cancer patients. Here we aimed to assess the prevalence of germline pathogenic variants in these 22 genes in a population-based Swedish...

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Source

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Identifiers

PMID: 33674644
DOI: 10.1038/s41598-021-84502-4
PMCID: PMC7935871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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