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Hsp90 modulates human sperm capacitation via the Erk1/2 and p38 MAPK signaling pathways

4 Mar 2021

Abstract excerpt

BACKGROUND: Heat shock protein 90 (Hsp90) is a highly abundant eukaryotic molecular chaperone that plays important roles in client protein maturation, protein folding and degradation, and signal transduction. Previously, we found that both Hsp90 and its co-chaperone cell division cycle protein 37 (Cdc37) were expressed in human sperm. Hsp90 is known to be involved in human sperm capacitation via unknown...

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PMID: 33663544
DOI: 10.1186/s12958-021-00723-2

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