Clinical phenotype of severe and moderate haemophilia: Who should receive prophylaxis and what is the target trough level?

Abstract excerpt

INTRODUCTION: One of the most often stated tenets of haemophilia care is that prophylaxis converts a person from a severe to a moderate phenotype. In this review, we argue that this is not an accurate assumption and that people on prophylaxis predominantly have factor VIII/IX levels in the mild range. MODERATE HAEMOPHILIA AND PROPHYLAXIS: People with moderate haemophilia, who are treating with on-demand regimens,...

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