Article
Underlying CTLA4 Deficiency in a Patient With Juvenile Idiopathic Arthritis and Autoimmune Lymphoproliferative Syndrome Features Successfully Treated With Abatacept-A Case Report.
Journal of pediatric hematology/oncology - 1 Nov 2021
Mazzoni Marta, Dell'Orso Gianluca, Grossi Alice, Ceccherini Isabella, Viola Stefania, Terranova Paola, Micalizzi Concetta, Guardo Daniela, Massaccesi Erika, Palmisani Elena, Calvillo Michaela, Fioredda Francesca, Malattia Clara, Dufour Carlo, Ravelli Angelo, Miano Maurizio
Abstract excerpt
BACKGROUND: Functional variants of the cytotoxic T-lymphocyte antigen-4 (CTLA4) could contribute to the pathogenesis of disorders characterized by abnormal T-cell responses. CASE PRESENTATION: We report a case of a 13-year-old girl who first presented with polyarticular juvenile idiopathic arthritis poorly responsive to treatment. During the following years the patient developed cytopenias, chronic...
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