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Insights and future directions of potential genetic therapy for Apert syndrome: A systematic review.

Gene therapy - 1 Nov 2021

Al-Namnam Nisreen Mohammed, Jayash Soher Nagi, Hariri Firdaus, Rahman Zainal Ariff Abdul, Alshawsh Mohammed Abdullah

Abstract excerpt

Apert syndrome is a genetic disorder characterised by craniosynostosis and structural discrepancy of the craniofacial region as well as the hands and feet. This condition is closely linked with fibroblast growth factor receptor-2 (FGFR2) gene mutations. Gene therapies are progressively being tested in advanced clinical trials, leading to a rise of its potential clinical indications. In recent years, research has...

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PMID: 33619359
DOI: 10.1038/s41434-021-00238-w

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