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Article

Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective

28 Jan 2021

Abstract excerpt

Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect microbial materials, sterile inflammatory insults, and certain host-derived elements. Inflammasomes, once activated, promote caspase-1–mediated maturation and secretion of pro-inflammatory cytokines, interleukin (IL)-1β and IL-18, leading to pyroptosis. Current advances in inflammasome research support their involvement in the...

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PMID: 33584697
DOI: 10.3389/fimmu.2020.613613

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