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Sperm proteins and cancer‐testis antigens are released by the seminiferous tubules in mice and men

10 Feb 2021

Abstract excerpt

Sperm develop from puberty in the seminiferous tubules, inside the blood-testis barrier to prevent their recognition as "non-self" by the immune system, and it is widely assumed that human sperm-specific proteins cannot access the circulatory or immune systems. Sperm-specific proteins aberrantly expressed in cancer, known as cancer-testis antigens (CTAs), are often pursued as cancer biomarkers and therapeutic...

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PMID: 33565176
DOI: 10.1096/fj.202002484r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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