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Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways

8 Feb 2021

Abstract excerpt

Recently developed arbovirus control strategies leverage the symbiotic bacterium Wolbachia , which spreads in insect populations and blocks viruses from replicating. While this strategy has been successful, details of how this “pathogen blocking” works are limited. Here, we use a combination of virus infections, fly genetics, and transcriptomics to show that Wolbachia and virus interact at host nucleotide...

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PMID: 33563832
DOI: 10.1128/mbio.03472-20

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