Article
Computer-aided design of PVR mutants with enhanced binding affinity to TIGIT.
Cell communication and signaling : CCS - 8 Feb 2021
Zhou Xiaowen, Du Jiangfeng, Zhou Xiuman, Niu Xiaoshuang, Li Wanqiong, Chen Chunxia, Lv Sifan, Wu Aijun, Gou Shanshan, Sun Yixuan, Zhai Wenjie, Qiu Lu, Qi Yuanming, Zhao Wenshan, Gao Yanfeng
Abstract excerpt
BACKGROUND: TIGIT, as a novel immune checkpoint molecule involved in T cell and NK cell anergy, could induce the immune tolerance and escape through binding with its ligand PVR. Blockade of TIGIT/PVR is considered as a promising strategy in cancer immunotherapy. However, to facilitate the design of inhibitors targeting TIGIT/PVR, the structural characteristics and binding mechanism still need to be further...
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