Article
Efficacy of platinum-based chemotherapy and prognosis of patients with pancreatic cancer with homologous recombination deficiency: comparative analysis of published clinical studies.
ESMO open - 1 Jan 2020
Pokataev Ilya, Fedyanin Mikhail, Polyanskaya Elizaveta, Popova Anna, Agafonova Julia, Menshikova Sophia, Tryakin Alexey, Rumyantsev Alexey, Tjulandin Sergei
Abstract excerpt
The aim of our study was to determine the effect of homologous recombination deficiency (HRD) on prognosis and efficacy of platinum-based chemotherapy in patients with pancreatic cancer (PC). We performed PubMed and Embase database queries. We included 4 studies into the meta-analysis and 16 studies in the systematic review. Our systematic analysis showed that the average weighted median overall survival (OS) in...
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