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Abnormal screens among nonmutation carriers in the High Risk Ontario Breast Screening Program.

The breast journal - 1 May 2021

Castelo Matthew, Brown Zachary, Schellenberg Angela E, Mills Jane K, Eisen Andrea, Muradali Derek, Grunfeld Eva, Scheer Adena S

Abstract excerpt

BACKGROUND: The Ontario Breast Screening Program was expanded in 2011 to offer annual MRI and mammography to women with high-risk genetic mutations (e.g., BRCA1/2) and women with strong family histories and ≥25% estimated lifetime risk of breast cancer. Data to support high-risk screening is less clear in the nonmutation carrier group, as MRI has lower specificity among this population. The potential unintended...

Topics

Breast Neoplasms
Cross-Sectional Studies
Early Detection of Cancer
Female
Humans
Magnetic Resonance Imaging
Mammography
Mass Screening
Mutation
Ontario
Retrospective Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33550650
DOI: 10.1111/tbj.14185

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