Article
Fixation probabilities in graph-structured populations under weak selection.
PLoS computational biology - 1 Feb 2021
Allen Benjamin, Sample Christine, Steinhagen Patricia, Shapiro Julia, King Matthew, Hedspeth Timothy, Goncalves Megan
Abstract excerpt
A population's spatial structure affects the rate of genetic change and the outcome of natural selection. These effects can be modeled mathematically using the Birth-death process on graphs. Individuals occupy the vertices of a weighted graph, and reproduce into neighboring vertices based on fitness. A key quantity is the probability that a mutant type will sweep to fixation, as a function of the mutant's...
Topics
- Algorithms
- Biological Evolution
- Computer Simulation
- Genetic Drift
- Humans
- Mathematics
- Models, Genetic
- Mutation
- Neoplasms
- Population Dynamics
- Probability