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Article

Defining inclusion criteria and endpoints for clinical trials: a prospective cross-sectional study in CRB1-associated retinal dystrophies.

Acta ophthalmologica - 1 May 2021

Talib Mays, van Schooneveld Mary J, Wijnholds Jan, van Genderen Maria M, Schalij-Delfos Nicoline E, Talsma Herman E, Florijn Ralph J, Ten Brink Jacoline B, Cremers Frans P M, Thiadens Alberta A H J, van den Born L Ingeborgh, Hoyng Carel B, Meester-Smoor Magda A, Bergen Arthur A, Boon Camiel J F

Abstract excerpt

PURPOSE: To investigate the retinal structure and function in patients with CRB1-associated retinal dystrophies (RD) and to explore potential clinical endpoints. METHODS: In this prospective cross-sectional study, 22 patients with genetically confirmed CRB1-RD (aged 6-74 years), and who had a decimal best-corrected visual acuity (BCVA) ≥ 0.05 at the last visit, were studied clinically with ETDRS BCVA, corneal...

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PMID: 33528094
DOI: 10.1111/aos.14597
PMCID: PMC8248330

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