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Article

Brain and Placental Pathology in Fetal COL4A1 Related Disease.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society - 1 Jan 2000

Shannon Patrick, Hum Courtney, Parks Tony, Schauer G M, Chitayat David, Chong Karen, Shinar Shiri, Blaser Susan, Moore Gaea, Van Mieghem Tim

Abstract excerpt

INTRODUCTION: Although fetal brain injury due to COL4A1 gene mutation is well documented, fetal central nervous system (CNS) and placental histopathology lack description. We report CNS and placental pathology in fetal cases with symptomatic COL4A1 mutation. METHODS: We retrieved four autopsy cases of COL4A1 related disease, confirmed by genetic sequencing after fetal brain injury was detected. RESULTS: One case...

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Identifiers

PMID: 33475042
DOI: 10.1177/1093526620984083

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