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Derivatisation of metronidazole enhances cytotoxic effect against Acanthamoeba genotype T4 isolates and leads to cytomorphological changes in trophozoites.

Acta tropica - 1 Apr 2021

Dušeková Aneta, Garajová Mária, Lukáč Miloš, Mrva Martin

Abstract excerpt

Amoebae of the genus Acanthamoeba are worldwide distributed causative agents of serious human infections such as granulomatous amoebic encephalitis (GAE) and Acanthamoeba keratitis (AK). To date, treatment of these infections is non-uniform and frequently unsuccessful. Recently, the phosphonium salts were studied for their high levels of antimicrobial activity. This work was aimed to investigate the cytotoxic...

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PMID: 33465352
DOI: 10.1016/j.actatropica.2021.105830

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