Article
Prevalence of the Factor V Leiden Mutation Arg534Gln in Western Region of Saudi Arabia: Functional Alteration and Association Study With Different Populations.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 Jan 2000
Athar Mohammad, Abduljaleel Zainularifeen, Ghita Ibrahim S, Albagenny Amani A, Halawani Saeed H, Alkazmi Mohammad M, Elbjeirami Wafa M, Alquthami Khalid, Alkhuzae Mohammad M, Ragab Fadel M, Al-Allaf Faisal A
Abstract excerpt
The rare Gln534 (Factor V Leiden; FVL) allele (1:169,519,049 T>C) is associated with an increased risk of venous thrombosis. The purpose of this study was to measure the prevalence of Factor V Leiden mutation in thrombophilia patients with deep vein thrombosis. Also, we investigated the functional and structural characteristics of this mutation p.(Arg534Gln) to be examined the cumulative impact on venous...
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