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Single-cell transcriptome analysis of uncultured human umbilical cord mesenchymal stem cells

7 Jan 2021

Abstract excerpt

Umbilical cord mesenchymal stem cells (UC-MSCs) have certain advantages over other MSCs and about 300 clinical trials have been registered using UC-MSCs to treat diseases such as osteoarthritis, autoimmune diseases, and degenerative disorders, yet, only limited success has been achieved. One reason is that in vitro expanded UC-MSCs show tremendous heterogeneity and their relationship to in vivo UC-MSCs remains...

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PMID: 33413643
DOI: 10.1186/s13287-020-02055-1

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