Genetic variants in m6A regulators are associated with gastric cancer risk.

doi:10.1007/s00204-020-02958-1

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Genetic variants in m6A regulators are associated with gastric cancer risk.

Archives of toxicology - 1 Mar 2021

Wang Xiaowei, Guan Dan, Wang Dafei, Liu Hanting, Wu Yanling, Gong Weida, Du Mulong, Chu Haiyan, Qian Jing, Zhang Zhengdong

Abstract excerpt

N6-methyladenosine (m6A) modification plays a vital regulatory role in tumorigenesis and development. In this study, we determined that the mRNA expression of IGF2BP1, IGF2BP2 and IGF2BP3, as the m6A modification genes, was significantly increased in gastric cancer (GC) tissues. Using a logistic regression model, we found that novel single-nucleotide polymorphism (SNP) rs9906944 C > T in IGF2BP1 was remarkably...

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PMID: 33398416
DOI: 10.1007/s00204-020-02958-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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