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Sensitive universal detection of blood parasites by selective pathogen-DNA enrichment and deep amplicon sequencing

2 Jan 2021

Abstract excerpt

BACKGROUND: Targeted amplicon deep sequencing (TADS) has enabled characterization of diverse bacterial communities, yet the application of TADS to communities of parasites has been relatively slow to advance. The greatest obstacle to this has been the genetic diversity of parasitic agents, which include helminths, protozoa, arthropods, and some acanthocephalans. Meanwhile, universal amplification of conserved...

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PMID: 33388088
DOI: 10.1186/s40168-020-00939-1

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