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Article

Dacomitinib induces objective responses in metastatic brain lesions of patients with EGFR-mutant non-small-cell lung cancer: A brief report.

Lung cancer (Amsterdam, Netherlands) - 1 Feb 2021

Peng Wenying, Pu Xingxiang, Jiang Meilin, Wang Jingyi, Li Jia, Li Kang, Xu Yan, Xu Fang, Chen Bolin, Wang Qianzhi, Cao Jun, Chen Yong, Wu Lin

Abstract excerpt

OBJECTIVE: Dacomitinib is a potent, irreversible and pan-HER tyrosine kinase inhibitor (TKI) of epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC). Currently, evidence of its activity on brain metastasis is lacking. MATERIALS AND METHODS: NSCLC patients diagnosed at Hunan Cancer Hospital between July, 2019 and July, 2020 with enhanced MRI-detected brain metastasis prior to treatment...

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PMID: 33352385
DOI: 10.1016/j.lungcan.2020.12.008

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